U.S. and Rwandan researchers said Wednesday they have developed a low-cost smartphone accessory that can detect HIV and syphilis from a finger prick of blood in just 15 minutes.
This is the first device that replicates all the functions of a lab-based blood test, and it works by detecting markers of the infectious diseases: HIV antibody, treponemal-specific antibody for syphilis, and non-treponemal antibody for active syphilis infection.
The manufacturing cost of the device is only 34 U.S. dollars, much lower than the 18,000 dollars that current gold standard of diagnostics, known as the enzyme-linked immunosorbent assay (ELISA) , needs
The accessory was recently piloted by health care workers in Rwanda who used it to test blood finger-pricked from 96 patients, many of whom were women at risk for mother-to-child transmission of the sexually transmitted diseases. The health care workers were given only 30 minutes of training on the device.
The researchers said that the device delivered test results displayed on the phone screen within 15 minutes and performed almost as well as the ELISA test.
Nearly all patients preferred it to lab-based tests, which could take up to two or more hours.
“Our work shows that a full laboratory-quality immunoassay can be run on a smartphone accessory,” lead author Samuel Sia, associate professor of biomedical engineering at the Columbia University.
“This kind of capability can transform how health care services are delivered around the world,” Sia said.
The device, or dongle, can easily connect to a smartphone or computer. It is small and light enough to fit into one hand and draws all the power it needs to run by plugging into a smartphone’ s audio jack.
Researchers believed that this lab-on-a-chip device could help scale up early detection of HIV and syphilis, especially in mobile or field clinics.
“Our dongle presents new capabilities for a broad range of users, from health care providers to consumers,” Sia said.
“By increasing detection of syphilis infections, we might be able to reduce deaths by 10-fold. And …we might be able to scale up HIV testing at the community level with immediate antiretroviral therapy that could nearly stop HIV transmissions and approach elimination of this devastating disease,” he added.
The work, also comprising researchers from Rwanda Biomedical Center, was published in the U.S. journal Science Translational Medicine.
May 29, 2015 at 3:04 am
Pretty! This has been a really wonderful post. Thanks
for providing this info.